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Supplementing with 3g daily shows no adverse effects or current contraindications (5), however, it may not even be necessary to dose it this high to begin with

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Metformin promotes weight loss by regulating the bodys response to insulin, reducing blood sugar levels, decreasing appetite cravings, and lowering the tendency to store fat, especially belly fat

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Most studies have been small, short term, or conducted in animal models rather than large human trials