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However, considerable amounts of ROS at the molecular level can cause cellular and tissue damage, damaging nucleic acids, proteins, organelles, and membranes and inducing cell death or apoptosis (40, 41)

This research positions gastrointestinal and oral chemosensors as a novel and non-invasive therapeutic target for managing metabolic syndrome and cognitive decline, overcoming the limitations of systemic bioavailability. Bitter compounds in plant foods have known health benefits, but the mechanisms underlying their effects in the body are still not fully understood

Insertion of autologous and allogeneic CLCs in the NP has been shown to retard IVD degeneration in various species without inducing any appreciable host-versus-graft response [21, 28, 29]

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The studies also met a key secondary endpoint, endoscopic improvement