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You can't study fat loss when the intervention makes subjects 30% hungrier

In the weight-loss cohort, 57.6% of participants were given dietary advice at some time point during the 4-year baseline period, 52.7% reported that they initiated a weight-loss diet, 27.0% received a weight-loss medication and 1.1% were referred for bariatric surgery (CPRD GOLD) or underwent bariatric surgery (Hospital Episode Statistics)

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One of the most debilitating consequences of this dysregulation is neuroinflammation, which patients commonly experience as profound brain fog, cognitive impairment, and memory deficits