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With an increase in calcium oxalate concentration, the expression of p53, ACSL4 and TRC in renal tubular epithelial cells increased, while the expression of SLC7A11 and GPX4 decreased significantly, indicating the centrality of ferroptosis in CaOx crystal-induced renal injury [171]

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[DOI] [PubMed] [Google Scholar] Dan HC, Cooper MJ, Cogswell PC, Duncan JA, Ting JP, Baldwin AS (2008) Akt-dependent regulation of NF-kappaB is controlled by mTOR and Raptor in association with IKK