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While the exact mechanisms remain to be agreed upon, both in vitro and in vivo experiments suggested several potential pathways for APOE4, including enhancing A production (promoting APP transcription and processing), facilitating A aggregation (interaction with soluble and fibrillary A aids in seeding/oligomerization/protofibril formation), and impairing A clearance (disrupted glial and enzymatic A degradation functions, and A removal rate from the brain)

Insights from a clinical trial involving nearly 200 nursing home residents in the Netherlands (mean age: 86

doi: 10.1093/humupd/dmaa045 72

Strength gains while on GLP-1 depend on training stimulus and nutrition, not which medication you take

You can read the pilot clinical trial in full for the methodology