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Rearrangement of (ribose-5-phosphate + xylulose-5-phosphate) to form sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate by transketolase : reversible Glyceraldehyde-3-phosphate is a glycolysis intermediate

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In addition to the tumorigenic effects of succinate accumulation, SDH5 mutation is the key driver supporting the acquisition of epithelialmesenchymal transition (EMT) characteristics