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Managing stress is extremely important in general, but more important for women with PCOS (PMOS)

So, proinflammatory and procoagulant proteins, including HMGB1, TNF?, ICAM1 and NFkB, disrupt the BBB and tight junction proteins, including ZO-1, occludin and claudin-5, are critical for the formation and maintenance of BBB integrity

PubMed, Parisis, Dorian, et al