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Nasal bioavailability is approximately 3-5%, which is sufficient because the peptide is extremely potent

The FDAs current safety page continues to cite concerns about immunogenicity, peptide impurities and limited safety data, and the agency has stated that a substance may still pose significant safety risks

For AF3 models (see Supplementary Fig

doi: 10.1021/acs.langmuir.0c02414 59 ZhaoT.LiuY

Brenner & Schedl, 2016 , quantified GLD-1 levels using antibody against GLD-1, and used GLD-1 staining in gld-1 null germlines to remove non-specific signal/background noise