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Using the Broad Institute's Connectivity Map (CMap), which compares gene expression signatures across thousands of compounds, Pickart et al

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Those target genes include heme oxygenase 1 (HMOX-1), the main regulator of iron and heme metabolism (Suzen et al., 2022), NAD(P)H quinone dehydrogenase 1 (NQO-1), a reducer of ROS (quinones) (Ross and Siegel, 2021), and peroxiredoxin (PRX), which reduces peroxides (Satoh et al., 2006