Individuals should be assessed for risk of sarcopenia and osteopenia, seen in individuals who are older, sedentary, chronically ill, malnourished, or with type 2 diabetes
The most common side effects are gastrointestinal and tend to improve after the first few weeks: Nausea, vomiting, or diarrhea (most common, especially early on) Constipation or stomach discomfort Reduced appetite Less common but serious side effects include pancreatitis, gallbladder issues, and low blood sugar particularly in patients taking diabetes medications
Temples corollary refers to the observation that drugs which caused a marked preponderance of lesser liver injuries compared with control agents, shown by more frequent serum aminotransferase elevations, were more likely to show more Hys Law cases
Initial studies in rats caused concerns over GLP-1 RAs causing thyroid cancer, but human studies are less clear on whether it is a concern.[ref] Decreased risk of substance abuse: A large 2026 study using data from the VA showed that GLP-1 RA drugs reduce the risk of developing a substance addiction (drugs, alcohol)
triple agonists suppress appetite and actively increase energy expenditure