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40,41 However, most of the prior LAMA studies were conducted in patients with moderate to severe COPD unlike the GOLDEN studies which, as mentioned previously, included a patient population that closely mimicked a real-world COPD population by including very severe patients, those with CV risk, and patients on background LABA

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However, the sample size in that study was small, as only 16 rats (eight per group) were used in their experiment, and the study duration was short (11 days), which may have affected the statistical significance and generalizability of the results