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Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist approved for type 2 diabetes management, chronic weight management, and in the case of Wegovy, cardiovascular risk reduction in certain patients

Through VDR signaling in enterocytes and immune cells, it preserves tight junction architecture and suppresses TLR4/NF-B activation, thereby limiting lipopolysaccharide-driven inflammation (232)

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It does not replace adequate nutrition, movement, strength training, sleep, behavioral support, or evaluation of symptoms that may have another cause