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The GLP-1 receptor activation is supraphysiological, meaning it far exceeds what the body would ever produce naturally

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doi: 10.1186/1758-5996-5-10

Since AgRP neurons are critically involved in neuroendocrine adaptations induced by weight loss 12, 16, 17 , control and AgRP GHR KO mice were further studied either in ad libitum or during 60% food restriction (F.R.)