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To estimate the number of hospitals subject to these requirements in the CY 2024 OPPS/ASC proposed rule with comment period, we leveraged the HIFLD hospital dataset to identify 8,013 total hospitals

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The propeptides are cleaved by endopeptidases after secretion into the extracellular space (extracellular activation) or before they are incorporated into storage vesicles (intracellular activation) [21, 22]

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These findings indicate that the peptide may influence receptor availability or receptor associated signaling complexes in experimental systems [4]