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It is important to emphasize that activation of the JAKSTAT3 pathway and the upregulation of GFAP should not be interpreted as substate-specific markers of astrocyte reactivity 139

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JHU083 also inhibits the expression of indoleamine 2,3-dioxygenase (IDO) in tumor cells, leading to decreased kynurenine levels and delayed tumor growth and metastasis by enhancing antitumor immune response (Oh et al., 2020)

This review provides an analysis of GLP-1 RAs and their multi-agonist derivatives as therapeutic agents for MASLD, examining their biological mechanisms and clinical efficacy based on current evidence

Using the clinical trial escalation protocol (2mg starting dose with 2mg increases every 4 weeks), reaching the 12mg maintenance dose takes approximately 20 weeks