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These molecules promote tissue damage by inducing oxidative stress and chronic inflammatory responses, significantly contributing to DKD progression and other diabetic complications, including cardiovascular disorders (191)

Melatonin acts as an antioxidant agent that detoxifies accumulated reactive oxygen or nitrogen species or modulates the balance of pro-oxidant and anti-oxidant enzyme activities by inhibiting pro-oxidative enzymes like xanthine oxidase (XO) and activating antioxidant enzymes such as catalase (CAT), glutathione peroxidase (GPX), and superoxide dismutase (SOD) [15, 199]