Searching for the physiological role of glucose-dependent insulinotropic polypeptide
Gclc mRNA and GSH levels were reduced in mice with Gclc specifically knocked out in the tumour (Fig
They include various free radicals and reactive molecules formed from molecular oxygen and nitrogen, including superoxide anion radical (O ), hydroxyl radical (OH ), hydrogen peroxide (H 2 O 2 ), singlet oxygen ( 1 O 2 ), nitric oxide (NO), and peroxynitrite (ONOO ) [28]
At high or chronic oxidative stress, however, the model suggests that the balance shifts towards GSSG, and removal of cysteine in the form of GSSG dominates, resulting in a decline in cysteine
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