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When butyrate binds to free fatty acid receptor 2 (FFAR2) and free fatty acid receptor 3 (FFAR3) on intestinal L cells, it stimulates GLP-1 release

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GLP-1 receptor agonists stimulate insulin secretion from pancreatic beta cells in a glucose-dependent manner, suppress glucagon release, slow gastric emptying, and act on central nervous system pathways to reduce appetite and food intake