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-22.5% Avg body weight loss at highest dose (SURMOUNT-1) 96% Lost at least 5% body weight 72 weeks Trial duration Context: Clinical trial participants also received lifestyle intervention (diet and exercise counseling)

Imidocarb, in particular, demonstrated an impressive average increase in toenail length of about 0.74 mm, while proflavine exhibited an increase of approximately 0.59 mm

Published clinical trials used continuous daily administration for 12-24 weeks without scheduled breaks, establishing this as a viable approach with maintained safety throughout the treatment period

The other NAD forms showed only modest increases in response to niacin, suggesting differential regulation of individual metabolite pools in steady state