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This process is exacerbated in individuals with Type 2 diabetes, characterized by chronic hyperglycemia, where elevated AGE levels are detectable in the plasma and serve as biomarkers for aging in diabetic patients, as shown in studies by Alexis [50] and Daniela [51]

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Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study Summary: This pilot Phase 1 study aimed to evaluate the safety, tolerability, and melanogenic (tanning) effects of Melanotan II in healthy volunteers

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