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In conclusion, the intricate interplay between metabolic diseases and protein homeostasis underscores the pivotal role of proteostasis networks, including the UPS, autophagy, and the UPR, in the pathogenesis of conditions such as obesity, T2DM, and MASLD (Fig

[DOI] [PubMed] [Google Scholar] 148.Zhang K, Shen X, Wu J, Sakaki K, Saunders T, Rutkowski DT, et al

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Oxidative stress-mediated macromolecular damage and dwindle in antioxidant status in aged rat brain regions: role of L-carnitine and DL-alpha-lipoic acid

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