Their dual benefits in glycaemic control and weight loss have made them an invaluable addition to the therapeutic landscape, yet their influence extends beyond clinical settings, impacting economic, cultural, and social realms (Wang et al., 2024)
47 Visceral fat accumulation in patients with obesity causes a number of changes (oxidative stress, activation of the RAAS and gut dysbiosis), resulting in insulin resistance, increased vascular stiffness, T2D, dyslipidaemia, hypertension, coronary atherosclerosis and, ultimately, HFpEF
However, both stress and physiological situations are often accompanied by increased protein secretion, requiring correct oxidative protein folding and hence, may affect the redox homeostasis of the periplasm
The cleanest way to hold the difference in mind is to count hormonal axes and ask what each does to the energy-balance equation
Lasbleiz A, et al