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Following intravenous administration, plasma clearance of valsartan is about 2 L/h and its renal clearance is 0.62 L/h (about 30% of total clearance)

Ischemia-reperfusion injury in the heart and kidney also involves ferroptotic pathways, underscoring the importance of specific modulation based on the context

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The bioavailability of NO is reduced in VDR knockout mice, leading to an increase in arterial stiffness [142]