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Based on Phase 2 clinical trial protocols conducted by Eli Lilly, initiation was typically at 2 mg administered once weekly via subcutaneous injection

Jackson MJPS, Bolaos J, Bruckdorfer R, Carlssen H, Elliot RM, Flier J, Griffiths HR, Heales S, Holst B, Lorusso M, Lund E, Moskaug JO, Moser U, Di Paola M, Polidori MC, Signorile A, Stahl W, Via-Ribes J, Astley SB: Antioxidants, reactive oxygen and nitrogen species, gene induction and mitochondrial function

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For weeks, mobility is restricted, and pain discourages full range of motion

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