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The results of several large randomized controlled trials indicated that maintaining blood glucose at near normal concentrations was the most important step in limiting the risk of diabetic neuropathy and lower extremity amputation (70-72)

For comparison, the FDA's 2003 guidance on pharmacokinetics in patients with impaired hepatic function recommends that drugs primarily cleared by the liver undergo dedicated studies across Child-Pugh categories A, B, and C [9]

In addition, GSSG retained in mitochondria during oxidative stress can lead to the S-gluthionylation of target proteins with mitochondrial dysfunction (20, 21)

The regulation of AMP-activated protein kinase by H2O2

[DOI] [PubMed] [Google Scholar] 103.Han L, Hiratake J, Kamiyama A, Sakata K