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Quantitative analysis of NAD synthesisbreakdown fluxes

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Because the brain is rich in fatswhich are particularly susceptible to oxidative damageit requires a robust antioxidant defense

Bioactive Vitamin B12 form for enhanced absorption

We then built the isobologram of the corresponding dose-response curves with a fixed dose ratio of R and compared the expected mixture of the two doses that produced an effect equal to half of the maximal effect produced by the individual drugs and to the experimental value (see later in methods)