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you feel full sooner and for longer, and 2) a disruption of the dopamine receptor, meaning the good feeling of eating something that you enjoy is not as rewarding

For example, the deletion of the core clock gene Bmal1 in the mouse brain led to astrocyte activation - an established marker of brain and neuronal injury - as well as synaptic degeneration [179]

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The aged mice exhibited a longer healthspan, exerted greater physical activity, and researchers observed less disability such as cardiac diseases and musculoskeletal dysfunction, etc

Kidney and cardiovascular effectiveness of SGLT2 inhibitors vs GLP-1 receptor agonists in type 2 diabetes