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LOX-mediated peroxidation of PE-PUFA generates lipid hydroperoxides (PE-AA/AdA-OOH) and hydroxyl radicals (OH), key ferroptosis executioners

In some embodiments, the otic formulations or compositions disclosed herein comprise PF-127, 188 (F-68 grade), 237 (F-87 grade), or 338 (F-108 grade)

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GHRH receptor occupancy increases baseline somatotroph activity, while Ipamorelin suppresses somatostatin tone that would normally dampen the pulse