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These indicator metabolites readily traverse mitochondrial and plasma membranes out of the cell of origin and into destination cells where they impact the use of shared cofactors and reactions involving those shared cofactors, as previously illustrated (Figures 1, 2)

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Sever et al., 2019), no portal hypertension development and reversal of the already preexisting portal hypertension to normal values (Sever et al., 2019) have become possible