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What stood out: CagriSema achieved 23.0% weight loss at 84 weeks (efficacy estimand) Tirzepatide achieved 25.5% On the treatment-regimen estimand, weight loss was 20.2% vs 23.6% Primary endpoint not met: CagriSema did not demonstrate non-inferiority vs tirzepatide on weight loss at 84 weeks Why this matters This is a reminder that in obesity pharmacotherapy, very effective and best-in-class are not the same conversation

The research chemical market Most peptides circulate as "research chemicals" sold for laboratory use only

For beginners, our favorite three with incredible safety profiles are choline (specifically alpha-GPC or citicoline), acetyl L-carnitine (ALCAR) , and L-tyrosine

doi: 10.3390/cells8121596 137 CheungTTMcInnesIB