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Enhanced tumor growth in brain dopamine-depleted mice following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment

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The longer the dissolved medication stays in contact with the oral mucosa, the more opportunity there is for absorption through the sublingual and buccal tissues

The treatment groups received topical application of escin gel at concentrations of 20%, 10%, 2%, and 0.5% for 4 weeks

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