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The entry of copper ion carriers into the cell leads to copper accumulation, which in-turn, triggers oxidative stress and induces cell death (Fig

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van Eijk, M., Boerefijn, S., Cen, L., Rosa, M., Morren, M., van der Ent, C.K., et al., Med

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Together, they create a continuous cycle of NO production and protection , maintaining higher levels of bioavailable NO for longer periods