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In these processes, HDAC5 deacetylates STAT3 at Lys685 and phosphorylates STAT3 at Tyr705, and thus regulates STAT3 localization and transcriptional activity to accelerate the leptin signaling [187]

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Proc Natl Acad Sci USA 96 : 73247329 Yakar S et al

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Introducing hundreds of millions of new organisms disrupts that balance, and disruption comes with symptoms