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This rare autosomal recessive genetic disorder caused by DPP1 gene (CTSC) mutations occurs with an incidence of approximately 1-4 per million ( This unique clinical phenotype strongly supports DPP1 inhibition strategy feasibility, indicating that even with severely reduced NSP activity, overall immune defense function can remain essentially intact

We investigate how each of these cell types adopts its distinct morphological features and how skin cells and neurons influence each other?s morphogenesis

However, much of the available research is preclinical

Dihexa was administered intraperitoneally (i.p.) at 0.5 mg/kg in phosphate buffered saline (PBS) on alternate days, commencing 15 days post-surgery and continuing through day 48, with control animals receiving PBS alone