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There are three different UPR signaling pathways in ERS response that are mediated by (1) RNA-dependent protein kinase-like ER kinase (PERK), (2) activated transcription factor 6 (ATF6), and (3) inositol-required enzyme 1 (IRE1) (69)

If you are considering stopping semaglutide or changing your schedule for any reason, contact your PlexusDx provider firstthey can advise on whether a break is safe or whether adjusting your dose is a better option