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Weve talked about this beforeespecially how insulin resistance and hormonal imbalance drive fat storage and make weight loss feel impossible GLP-1 medications help regulate that systembut they dont replace the need to support it

In other words, the drugs have to demonstrate a certain amount of weight loss, says Kushner

A meta-analysis of clinical trials found that the use of pioglitazone, a TZD, was associated with significant improvements in depressive symptoms

Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1 SU) Diabet Med

"I've seen patients feel great