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There are combination protocols where it is hard to know which ingredient caused the result

The FDA has expressed concerns about compounded versions, noting they "received multiple reports of adverse events, some requiring hospitalization, that may be related to dosing errors associated with compounded injectable semaglutide products." However, many patients used compounded versions successfully under proper medical supervision.

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intravenous plus aerosolized colistin for treatment of ventilator-associated pneumonia-A matched case-control study in neonates