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Kidney function significantly affects exenatide and lixisenatide clearance, but medications like semaglutide, tirzepatide, dulaglutide, and liraglutide undergo proteolytic degradation and do not require renal dose adjustments

Liu L, Gao B, Wang J, Yang C, Wu S, Wu Y, et al

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Evid Based Complement Alternat Med 2012(1):323784 Yang B, Xiao B, Sun T (2013) Antitumor and immunomodulatory activity of Astragalus membranaceus polysaccharides in H22 tumor-bearing mice