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We're talking half-lives of 2-4 weeks instead of days

Emerging evidence suggests that GLP-1 receptors are not confined to pancreatic islets but are also expressed in cardiomyocytes and vascular endothelial cells (50, 51)

doi: 10.1016/j.neuroscience.2014.02.022 180 ZhangSXCaiHYMaXWYuanLZhangJWangZJet al

It does not provide in vivo dosing, animal-study, clinical, diagnostic, or therapeutic guidance, and does not constitute medical, clinical, veterinary guidance or treatment advice.

There was also evidence that among a subgroup of smokers, those receiving semaglutide had a greater reduction in cigarettes per day than those receiving placebo