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While glutathione is generally recognized as safe (GRAS), there are some potential side effects associated with glutathione treatment

Responses of gut microbiota to diet composition and weight loss in lean and obese mice (in Eng)

Life-threatening events are seen when greater than 150 to 200 mg/kg of caffeine is consumed, and fatalities have been reported when 5 to 50 g of caffeine was ingested

Altogether, the enteroendocrine system represents an attractive therapeutic target for treating metabolic disease as the pleiotropic effects of different gut hormones can be exploited individually

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