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Thus, by activating the coagulationinflammation axis, worsening the local microenvironment, promoting urate crystal aggregation, and accelerating tissue fibrosis, hypercoagulability contributes significantly to tophus development and persistence

Risk Of Renal Injury Cases of acute renal failure with acute tubular necrosis, renal impairment, and urine calcium oxalate crystals have been reported

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This confirmed an earlier report of efficacy of boswellia for ulcerative colitis patients (Gupta 1997)

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