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Meta-analyses have further confirmed that dual GLP-1/GIP receptor agonists are more effective than single GLP-1RAs in reversing liver fibrosis and reducing hepatic fat accumulation, suggesting a dose-dependent and receptor-combinatorial effect on liver outcomes (48)

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Considering the documented changes in sensitization and upregulation of TRPV1 in the complete Freunds adjuvant (CFA)-induced inflammatory pain model, CFA was utilized to induce chronic inflammatory pain in mice 43

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