This underscores the complexity of KOAs pathological mechanisms and the urgent need to develop novel therapeutic paradigms
H 2 O 2 has a longer half-life and can cross membranes (Sies, 2014), which confers properties to H 2 O 2 as a mitochondrial signal (Raimundo, 2014)
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Endocrine Endocrine dysfunction is frequently reported in patients receiving ICIs (5%-20%), with an average onset time within 12 weeks from treatment initiation, and higher incidence in patients receiving combination therapy compared with monotherapy