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HW TIPS TO MINIMIZE GI SIDE EFFECTS One or more gastrointestinal (GI) side effects are observed in roughly 10% to 50% of people who take one of these weight management medications.1,2 From nausea and vomiting to acid reflux, bloating, stomach cramps, diarrhea, and/or constipation, patients can minimize GI side effects with a start low, go slow approach, starting with the lowest dose and titrating as recommended (see table Currently FDA-Approved Mono and Dual Agonists)

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring neuropeptide first identified in the brain for its ability to promote deep, restorative sleep

elevations suggest disrupted junction function and increased permeability

[6] But the program did not advance to pivotal efficacy trials