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In conclusion, ESSENCE establishes semaglutide as a cornerstone therapy for MASH with F2-F3 fibrosis in metabolically high-risk patients, providing robust histologic improvement, substantial weight loss, and broad cardiometabolic benefit

The Journal of biological chemistry 279 , 3984639855, doi: 10.1074/jbc.M403835200 (2004)

When taken, blood pressure comes down

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