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Among the tissues and organs crucial in regulating glucose and lipid metabolism, pancreas, brain, and adipocytes express GIP receptors (GIPRs), while pancreas, brain, and gastrointestinal tract are rich in GLP-1 receptors (GLP-1Rs) (40)

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Bariatric surgery yields substantial and sustained weight loss, although, due to the high cost and a small risk of serious complications, it is generally recommended only for patients with severe obesity

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