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All covariates and cell types were included in the SVA model to estimate the surrogate variables

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Among the proteins with oxidoreductase activity, the 4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1), involved in carnitine biosynthesis, and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) were higher expressed, whereas retinal dehydrogenase 1 (ALD1A1) was lower expressed in HMU cows

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