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As GLP-1 medications can produce significant and sustained weight loss, improvements in body weight and metabolic health likely play a role in the observed risk reduction

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For tumour xenograft experiments, athymic nude NU/J mice (The Jackson Laboratory, 002019) were used (female, at least 8 weeks old)

Taking advantage of the stable expression of the fluorescent membrane-targeted Tomato, MCs were seeded at a density of 1000 cells/cm in a plastic chamber slide coated with the distinct ECM proteins (-Slide 8 Well, Ibidi, Germany), and placed in a live-cell imaging system (Zeiss CellDiscoverer 7) equipped with a temperature- and CO 2 -controlled chamber