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NF-B and Nrf2 signaling pathways contribute to wogonin-mediated inhibition of inflammation-associated colorectal carcinogenesis

For the quantification of these metabolites in TIF samples, 5 l samples were extracted in 45 l ice-cold extraction solvent (75% acetonitrile, 25% methanol and 0.1% formic acid) containing isotope-labelled internal standards (36 M 13 C 2 , 15 N-GSH, 0.92 M 13 C 4 , 15 N 2 -GSSG and 10 M D 4 -cystine)

Nat Rev Drug Discov 10(4):292306 Priyadarsiny P, Khattar SK, Malik R, Udupa V, Seshaiah A, Rahman S, Shingatgeri VM, Bora RS, Saini KS (2008) Differential gene expression analysis of a known hepatotoxin, N -acetyl- p -amino-phenol (APAP) as compared to its non-toxic analog, N -acetyl- m -amino-phenol (AMAP) in mouse liver

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These findings of reduced oxidative stress status and MDA production supported the findings of the attenuating effect of the toxicity of the combined treatment ( T