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The common subtypes of migraine are primarily polygenic, involving complex interactions among multiple genetic variants, each contributing modestly to disease susceptibility (van den Maagdenberg et al., 2019)

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Potential limitations of both studies include the use of a single dose rather than multiple doses of cagrilintide and the use of doses (0.6 mg in the renal impairment study and 0.9 mg in the hepatic impairment study) lower than the 2.4 mg dose being evaluated in clinical development